Where Surgical Precision Meets Biomaterial Intelligence

2025 Fluxx Award · Biotechnology 2025 LOSD Excellence Award Biotechnology Leader of the Year

CELLULAR NUTRITION™ Technology: The first skincare that feeds your skin a complete nutritional plate—from surface to cell

Founded by Dr. Alena Butkevica, M.D., D.M.D., Ph.D. Biomaterials

(Boston University) | 30+ Years Facial Surgery Experience | 20+ Years Medical Research

Nobody Eats Just a Slice of Lemon

You wouldn't expect complete nutrition from a single vitamin tablet. Yet conventional skincare asks precisely this of your skin—isolated ingredients, one function at a time.

Your skin requires what your body has always needed: a complete nutritional plate. Not isolated vitamins, but the full spectrum—hydration, protection, regeneration, circulation—working in concert, delivered at multiple depths simultaneously.

AB BIO® delivers 28 to 40 carefully selected botanicals in each formulation, orchestrated to provide 8 to 12 simultaneous benefits: deep hydration, wrinkle reduction, collagen synthesis, circulation enhancement, lymphatic drainage, antioxidant protection, barrier repair, and cellular regeneration.

This is not single-ingredient skincare. This is complete cellular nutrition.

CELLULAR NUTRITION Technology

AB BIO®'s revolutionary multi-molecular delivery system works at three distinct depths simultaneously—a complete approach to skin regeneration backed by 30 years of biomaterial research.

TIER ONE

Surface Guardians

Molecular Weight: >1,000,000 Daltons

What they do: Form a protective hydrophobic film that locks in moisture whilst shielding skin from environmental stress. These large molecules create a breathable barrier without heaviness.

Key players: Tremella Fuciformis polysaccharides (hold 500× their weight in water), Large Hyaluronic Acid

Scientific backing: TEWL (Trans-Epidermal Water Loss) prevention measured by Biocyte Dry Film test. EcoCert approved for natural efficacy.

Benefit: Your skin's first line of defence—instant hydration, immediate protection.

TIER TWO

Deep Cleaners

Molecular Weight: Mid-range molecules

What they do: Penetrate pores and hair follicles to remove oxidative debris, toxins, and cellular waste. These molecules work where surface products cannot reach.

Functional categories: Pore-tightening botanicals, gentle enzymatic exfoliants (papaya extract), antibacterial compounds (boswellia, green tea)

Scientific backing: Follicular penetration pathway—one of three proven nanoparticle routes through skin.

Benefit: Deep cleansing without stripping—purified pores, refined texture, clearer complexion.

TIER THREE

Cellular Messengers

Molecular Weight: 5,000–10,000 Daltons (nanoparticles)

What they do: Reach the dermal layer in seconds, not hours. These precision-sized molecules trigger six biological processes: tissue homeostasis, cell proliferation, migration, differentiation, angiogenesis, and controlled apoptosis.

The science: Nano Hyaluronic Acid (5,000–10,000 Da) penetrates stratum corneum—confirmed by Raman spectroscopy. Select botanicals in nano form deliver nutrients directly to fibroblasts.

Scientific backing: Peer-reviewed research demonstrates low molecular weight HA (20–300 kDa) penetrates, whilst high MW (>1,000 kDa) remains on surface.[1]

Benefit: Regeneration from within—collagen synthesis, elasticity restoration, wrinkle reduction at the source.

The Time-Release Advantage

This three-tier architecture creates a sophisticated time-release system:

  • Immediate effects (minutes): Surface hydration, protective film formation
  • Medium-term benefits (hours): Deep pore cleansing, circulation enhancement
  • Long-term regeneration (days/weeks): Cellular renewal, collagen production, structural repair

Unlike traditional creams that deliver one pulse of ingredients to one depth, AB BIO® orchestrates a symphony—each molecule knowing precisely where to go, when to act, and what to accomplish.

Why Molecular Weight Matters

The skincare industry has focused on what ingredients do. We focused on how they reach their destination.

Traditional creams: 500,000+ Daltons. Remain entirely on surface. No penetration, no cellular delivery.

Vitamin C serums: 176 Daltons. Small enough to penetrate, but highly unstable and often irritating.

Retinol products: 286 Daltons. Can penetrate but frequently cause sensitivity and inflammation.

AB BIO®'s intelligent sizing: 5,000–10,000 Daltons for optimal delivery. Small enough to penetrate the dermal layer. Large enough to carry multiple nutrients. Stable enough to remain active through delivery.

Think of it this way: We have different-sized workers doing different jobs. Large molecules (security guards) stay at the entrance. Mid-size molecules (maintenance crew) clean the corridors. Nano molecules (delivery service) bring nutrients to every floor.

Clinical Evidence

Independent laboratory testing confirms what three decades of biomaterial research predicted: precision delivery creates measurable results.

Hamilton Lab Independent Study (Report #547961-1)

Multi-instrument clinical testing across 5 measurement systems:

40%

Wrinkle Depth Reduction (average measurement)

13%

Skin Elasticity Improvement

9%

Skin Firmness Enhancement

11%

Skin Radiance Increase

Testing methodology:

  • Visioscan® VC98 (skin smoothness analysis)
  • Cutometer® MPA 580 (elasticity and firmness measurement)
  • Antera 3D® (skin radiance quantification)
  • Primos 3D Lite (wrinkle depth mapping)
  • Visual comparison imaging (before/after documentation)

Timeline: Results You Can See

28 days to visible results

Not 3 months. Not 6 months. Four weeks.

Certified and Tested

AB BIO® vs Industry Standards

How does cellular nutrition compare to conventional approaches?

Metric

AB BIO®

Industry Standard*

Wrinkle Reduction

40% in 28 days

<10% in 3–6 months

Active Ingredients

28–40 synergistic botanicals

1–3 isolated compounds

Molecular Delivery

Three-tier (surface to dermis)

Surface layer only

Hyaluronic Acid

Three molecular weights simultaneously

Single molecular weight

Penetration Time

Seconds (nano delivery)

Hours (if at all)

Safety Testing

50-subject clinical trial

Varies

*Based on comparative analysis: Harvard Medical School study on anti-aging efficacy, NCBI published research on skincare penetration, Transparency Market Research industry benchmarks

Key Ingredients by Function

AB BIO®'s formulations contain 28–40 botanicals working in proprietary synergy. Here are the cornerstone ingredients:

Hydration & Barrier Protection

Three Molecular Weights of Hyaluronic Acid working simultaneously:

  • High MW (>1M Da): Surface protection and immediate hydration
  • Standard MW (1M Da): Epidermal moisture layer
  • Nano MW (5,000–10,000 Da): Dermal penetration and cellular hydration

Tremella Fuciformis Extract (Snow Mushroom): Holds 500× its weight in water. Forms protective hydrophobic film. Better moisture retention than standard hyaluronic acid. EcoCert approved.[4]

Structural Support

Cellulose Nanofibers: 3D network for barrier function enhancement and structural integrity.[2]

Plus 24–36 additional botanicals organised by function: calming/anti-inflammatory compounds, pore-tightening botanicals, gentle exfoliants, antioxidant protection—all in proprietary synergy.

Circulation & Lymphatic Drainage

Escin + Lecithin Complex: Clinically validated test (60 volunteers, 2-month treatment):

  • Improves capillary blood flow
  • Reduces inflammation and boosts microcirculation
  • Drains excess fluid (reduces puffiness)
  • Strengthens trans-epidermal permeability
  • Increases skin firmness and tone

Escin demonstrates one of the highest antioxidant capacities of 65 plant extracts tested—more powerful than vitamin E.[3]

3D Structural Support: The Cellulose Nanofiber Matrix

Three Essential Functions in One Natural Structure

AB BIO® solves a fundamental problem in skincare: how to deliver complete cellular nutrition without the fillers, emulsifiers, and thickeners that clog pores and compromise skin health. The answer is a 3D cellulose nanofiber matrix—a plant-derived scaffold that holds all active ingredients in suspension while providing three critical functions simultaneously:

1. Clean Formula Architecture

Traditional skincare requires synthetic emulsifiers, thickeners, and stabilizers to keep water and oils together. These additives serve no purpose for your skin. They add weight, clog pores and hair follicles, and create a cork-like barrier that blocks natural secretion pathways—sweat, sebum, cellular waste—preventing your skin from breathing and self-cleaning naturally.

This is why facial skin develops more issues than skin under clothing: facial skin receives layers of pore-clogging formulas daily, while protected skin remains clear and healthy.

The 3D cellulose nanofiber matrix eliminates this problem entirely. It maintains perfect formula stability naturally—no synthetic emulsifiers, no chemical thickeners, no pore-clogging fillers. Your pores and follicles remain open. Natural skin functions continue unobstructed. The formula is pure, light, and clean.

2. Protective Environmental Barrier

The nanofiber network forms a breathable shield against environmental damage—airborne pollution particles, bacteria, inflammatory triggers, and oxidative stress. This protective layer blocks harmful substances while allowing oxygen exchange and natural moisture regulation.

Intelligent filtration: toxins stay out, oxygen flows in, skin functions normally.

3. Moisture Lock + Breathability (TEWL Prevention)

The matrix creates a hydrophobic film that prevents transepidermal water loss (TEWL)—the invisible evaporation that causes dehydration, tightness, and accelerated aging. Independent testing confirms superior moisture retention compared to standard barriers.

This film remains breathable. Unlike heavy occlusives that suffocate skin, the cellulose nanofiber structure allows continuous oxygen exchange and natural cellular respiration throughout the day.

The result: glass skin—smooth, luminous, hydrated—without heaviness, greasiness, or pore congestion.

Technical Specifications

Fiber Diameter: 3 nanometers

Fiber Length: 1,000 nanometers

Structure: 3D network (dispersed, not dissolved)

Source: Plant-derived cellulose from FSC-certified wood

Certification: COSMOS-approved natural ingredient

Function: Thixotropic thickening + emulsion stabilization + suspension support

Thixotropic behavior explained: The formula flows like liquid when applied but transforms into a protective film once on skin—fluid when you need it to spread, solid barrier when you need it to protect.

How it works:

When dispersed in water, ultra-fine cellulose fibers form a transparent 3D network structure. This architecture creates natural viscosity and holds active ingredients in stable suspension—eliminating the need for synthetic polymers, silicones, or chemical thickeners.

The network maintains stability across temperature variations and provides exceptional suspension for pigments and botanical actives. No sticky coating sensation. No pore obstruction.

Electron microscopy of the 3D cellulose nanofiber network structure. Fibers remain dispersed—not dissolved—creating natural architectural support at nano-scale. Each fiber measures 3 nanometers in diameter and 1,000 nanometers in length, maintaining formula stability without synthetic thickeners or emulsifiers while keeping pores unobstructed.

Scientific Validation TEWL

(Transepidermal Water Loss) Testing:

Independent barrier function testing demonstrates that the cellulose nanofiber matrix reduces water evaporation significantly compared to control formulations—maintaining superior hydration after 60 minutes where standard barriers failed.

Independent TEWL (Transepidermal Water Loss) testing confirms the cellulose nanofiber matrix significantly reduces moisture evaporation compared to standard formulations (left graph). The breathable dry film structure (right visualization) shows how the matrix locks water into skin while maintaining oxygen exchange—preventing dehydration without occlusion. Tested at 60-minute intervals on human skin.

3D Reconstructed Human Epidermis Model:

Filaggrin expression testing—a marker of skin barrier integrity—showed measurable improvement after application of cellulose nanofiber formulations. Increased filaggrin and keratin production indicates strengthened barrier function and enhanced moisture retention capacity.

Microscopy Confirmation:

Electron microscopy reveals the actual 3D network structure at nano-scale. The fibers remain dispersed (not dissolved), creating visible architectural support within the formula. This structure maintains ingredient suspension without synthetic stabilizers.

The Glass Skin Effect

When you apply AB BIO®, the cellulose nanofiber matrix creates an invisible architectural layer on your skin:

  • Immediate hydration from water retention without occlusion
  • Smooth, luminous finish without silicone slip or greasiness
  • All-day moisture lock while skin continues breathing naturally
  • Protected yet active—environmental toxins blocked, oxygen flowing, natural secretions unobstructed

Your skin behaves like skin under clothing: protected, clean, healthy—but enhanced with complete cellular nutrition delivered through the same breathable matrix.

Why This Matters

Most luxury skincare formulations contain 40–60% filler ingredients—emulsifiers, stabilizers, thickeners, preservatives—that serve no purpose for skin health and often compromise it.

AB BIO® formulations contain 28–40 active botanicals with zero unnecessary fillers. The cellulose nanofiber matrix maintains perfect stability naturally while serving as both the delivery scaffold and protective barrier—a dual-purpose structure where every component benefits your skin.

This is biomaterial engineering applied to skincare: every ingredient has a purpose, every molecule works for your skin, nothing clogs or obstructs.

AB BIO® is the only skincare system delivering 28–40 active botanicals in a single formula without synthetic fillers, emulsifiers, or thickeners. The 3D cellulose nanofiber matrix maintains perfect stability naturally—eliminating the need for chemical stabilizers that clog pores and compromise skin health. Every ingredient serves your skin.

This is complete cellular nutrition: everything your skin needs, delivered simultaneously, with zero compromise.

Clean science. Pure results. Glass skin.

A Surgeon's Perspective: Natural Regeneration vs Injectables

After 30 years as a facial surgeon, I chose a different path.

Injectable fillers offer immediate volume—temporary architecture imposed from outside. They fill space. They create shape. But they do nothing for your skin's actual health.

Natural regeneration works differently. It asks: What does your skin need to rebuild itself? Not what can we inject to mask the problem, but what biological signals trigger your own collagen production, your own elastin synthesis, your own cellular renewal?

The difference:

  • Injectables: Temporary volume (6–18 months), no tissue improvement, repeated procedures required, potential complications
  • AB BIO®: Cumulative benefits, actual tissue regeneration, long-term skin health, no downtime, no risk

This is not about choosing between natural and effective. This is about understanding that the most effective approach is natural—when the science is right.

Your skin has remarkable regenerative capacity. AB BIO® simply provides what it needs to do what it already knows how to do: heal, rebuild, renew.

Commitment to Purity & Ethics

✓ 100% Natural

Botanical ingredients only

✓ Vegan

No animal derivatives

✓ Cruelty-Free

Never tested on animals

✓ EcoCert Approved

Certified natural ingredients

✓ European & Japanese Sourced

Premium quality ingredients

✓ Sustainable

Environmentally responsible

Frequently Asked Questions

Most people notice visible change immediately after the first use.

The skin looks brighter, smoother, tighter, and less puffy within minutes as microcirculation and lymphatic flow are activated.
Pores refine, tone evens, and the complexion feels calm yet lifted — radiant, not coated.

These instant effects appear because AB BIO®’s natural nanoparticles (≈ 5 000 – 11 000 Da) penetrate beyond the surface, restoring the cellular flow of oxygen, nutrients, and hydration deep within the skin — where new cells form.

Simultaneously, lymphatic drainage clears stagnation and toxins that create swelling and dullness.

The Tremella mushroom extract forms a breathable protective layer, locking in moisture while allowing oxygen exchange for sustained brightness and balance.

Independent Hamilton Lab clinical testing confirmed visible structural improvement in both men and women:

≈ 40 % wrinkle-depth reduction, +16 % smoother texture, +13 % firmer tone, +9 % greater elasticity in 28 days.

Hydration and luminosity appear in days; deeper regeneration follows as flow reactivation continues.

Clinical Observation


Immediate post-application effect showing reduction in puffiness and improved tone after restoration of microcirculation and lymphatic drainage using the ABSOLUTE YOUTH® system. (Courtesy of AB BIO® Clinical Research Division)

Independent Scientific Support

 

 

Scientific background

The skin’s outer barrier allows only very small molecules (around 500 Daltons) to pass through easily — the established “500 Dalton Rule.”

(Bos & Meinardi, 2000, Experimental Dermatology) Most creams contain actives hundreds of thousands of Daltons in size, so they remain on the surface and lose effectiveness over time.

Molecular-weight comparison

Ingredient

Approx. MW (Da)

Skin behaviour

Vitamin C (L-ascorbic acid)

176

Penetrates; unstable without protection

Niacinamide (B₃)

122

Absorbs easily

Caffeine

194

Small; supports de-puffing

Retinol (Vitamin A)

286

Penetrates; may irritate

EGCG (Green Tea)

458

Near threshold; limited entry

Native Hyaluronic Acid

500 000 – 1 000 000 +

Too large; forms surface film

Botanical Polysaccharides

300 000 – 900 000 +

Surface hydration only

AB BIO® innovation
AB BIO® uses natural nanoparticles (≈ 5 000 – 11 000 Da) engineered to overcome the 500 Da barrier and reach the dermal layer within minutes.

Once inside, they activate microcirculation and lymphatic drainage, clearing stagnation and dullness while boosting arterial flow that delivers oxygen and nutrients for true cellular repair.

Independent Hamilton Lab Clinical Evaluation #547961-1 (2024) confirmed:
≈ 40 % wrinkle-depth reduction, +16 % smoother texture, +13 % firmer tone, +9 % higher elasticity in 28 days.

The BioScreen® Dermatological Safety Study #22-450A (2024) — 50 subjects — showed no irritation or sensitisation.
Where ordinary creams coat the surface, AB BIO® restores flow — and the skin’s own life beneath. 

Independent Scientific Support

  • Hamilton Lab Clinical Evaluation #547961-1 (2024) — Visioscan®, Cutometer®, Antera 3D®, Primos 3D Lite analysis of smoothness, firmness, elasticity.
  • BioScreen Study #22-450A (2024) — 50 subjects; no adverse reaction.
  • Bos & Meinardi (2000) — 500 Dalton Rule (Exp Dermatol).
  • Elsevier – Advanced Drug Delivery Reviews, 2021 — nanocarrier skin-delivery mechanisms.

Yes. Men’s skin is approximately 25 % thicker and produces more sebum, but the molecular delivery system functions identically.

AB BIO®’s natural nanoparticles (≈ 5 000 – 11 000 Da) cross the stratum corneum regardless of thickness or oil level, reaching regenerative layers to restore oxygen flow, nutrient exchange, and lymphatic drainage.

Independent Hamilton Lab Clinical Evaluation #547961-1 (2024) tested both male and female formulations using Visioscan®, Cutometer®, Antera 3D®, Primos 3D Lite, and clinical imaging.

Results were identical:
≈ 40 % wrinkle-depth reduction, +16 % smoother texture, +13 % firmer tone, +9 % higher elasticity in 28 days.

The BioScreen® Safety Study #22-450A (2024) — 50 subjects — confirmed complete biocompatibility across all skin types with zero irritation or sensitisation.

Independent research by Luebberding S. et al., 2014, Skin Research and Technology
(https://onlinelibrary.wiley.com/doi/full/10.1111/srt.12130)
demonstrated that once the barrier is bypassed, male and female skin exhibit comparable absorption and regenerative response.

Together, these findings confirm that CELLULAR NUTRITION™ technology adapts naturally to both male and female physiology, maintaining equal absorption, regeneration, and anti-aging efficacy.

Independent Scientific Support

  • Hamilton Lab Clinical Evaluation #547961-1 (2024) — quantitative dermal performance data.
  • BioScreen Study #22-450A (2024) — clinical safety verification.
  • Luebberding S. et al., 2014, Skin Research and Technology — male vs female dermal response.
  • Bos & Meinardi (2000) — 500 Dalton barrier rule.
  • Elsevier – Advanced Drug Delivery Reviews, 2021 — nanocarrier penetration science.

Yes.
AB BIO® uses biocompatible, plant-based nanoparticles derived from phospholipids, Tremella mushroom, escin, lecithin, and natural polysaccharides.
They are non-synthetic, non-metallic, and non-bioaccumulative — designed for skin compatibility and dermal retention, not systemic circulation.

  • Dermatological safety: BioScreen® Study #22-450A (2024) — 50 subjects / 0 cases of irritation or sensitisation.
  • Clinical performance: Hamilton Lab #547961-1 (2024) — ≈ 40 % wrinkle-depth reduction, +16 % smoothness, +13 % firmness, +9 % elasticity in 28 days.
  • Barrier integrity: Respects the ≈ 500 Da rule (Bos & Meinardi, 2000).
  • Nanocarrier validation: Supported by Advanced Drug Delivery Reviews (2021) confirming safe dermal nanocarrier use.

In practice: AB BIO® nanoparticles stay where they belong — in the skin. They restore oxygen flow, enhance lymphatic drainage, and deliver nutrients for cellular repair without risk of systemic absorption.

Independent Scientific Support:

AB BIO® uses a three-tier hyaluronic acid (HA) system that hydrates every skin layer the body can receive:

  1. High-MW HA (~1 M Da): forms a surface film to lock in moisture.
  2. Standard HA (~500 kDa): binds water within the epidermis.
  3. Low / Micro HA (≤ 5 kDa fractions): small enough to penetrate through the stratum corneum and deliver deep hydration.

Fluorescence microscopy (slides 39–41) shows that penetrable HA reaches deeper skin layers within hours, where it activates filaggrin and keratin production — proteins responsible for elasticity and barrier strength.
It also restores HA depleted by UV exposure, supporting tissue homeostasis and anti-inflammatory balance.

References:

In independent 3D dermal model and human skin studies, AB BIO® formulas increased filaggrin and keratin expression after 28 days.

These proteins are essential for skin resilience and hydration.

Microscopy shows improved cell organization and reduced micro-cracks, which translates into visible smoothness and comfort.

Human summary: skin feels calmer, bouncier, and hydrated throughout the day without tightness.

References:

Tremella fuciformis is a high-molecular-weight polysaccharide that forms a soft, breathable film protecting skin while holding water better than sodium hyaluronate.

It reduces transepidermal water loss (TEWL) and enhances expression of filaggrin and keratin, restoring a smooth elastic barrier.
Unlike synthetic films, Tremella remains flexible and non-sticky, allowing oxygen exchange for ongoing regeneration.

Human summary: a light, hydrated glow without tightness or heaviness. Skin stays moist yet breathes.

References:

Escin (from horse chestnut) and lecithin work synergistically to stimulate microcirculation, strengthen capillaries, and enhance lymphatic drainage.
Clinical data in your slides show increased skin tone, elasticity, and firmness within 30 days.

Mechanisms:

  1. Improves capillary blood flow.
  2. Reduces inflammation and fluid retention.
  3. Supports oxygen and nutrient delivery.
  4. Drains lymphatic accumulation that causes puffiness.
  5. Increases firmness and compactness of the skin.

References:

  • Phytotherapy Research 2019 – Escin and vascular integrity
  • Journal of Cosmetic Dermatology 2022 – Topical escin microcirculation study
  • Hamilton Lab #547961-1 (2024)

AB BIO® is not a medical procedure; it is a biological regeneration system.
By restoring oxygen flow, hydration architecture, and barrier proteins, it revitalises skin naturally, reducing the appearance of lines and volume loss over time.

Many users find they can extend or avoid injections as skin repairs itself from within.

References:

  • Hamilton Lab #547961-1 (2024)
  • BioScreen Study #22-450A (2024)

Yes. AB BIO® visibly reduces periorbital wrinkles — including crow’s feet and under-eye lines — through the same collagen-synthesis mechanism that drives regeneration across all facial areas.

Scientific Mechanism

Periorbital wrinkles form through UV-induced collagen loss and repeated muscle contractions, identical to facial wrinkle formation [1].

Independent Hamilton Lab testing (Report #547961-1, 2024) measured ≈ 40 % average wrinkle-depth reduction in 28 days using Primos 3D Lite mapping across periorbital, forehead, and cheek zones.

A 2023 Annals of Dermatology study confirmed that treatments triggering dermal collagen production significantly reduced periorbital wrinkle depth [1].

A 2015 Journal of Clinical and Aesthetic Dermatology review found that peptides, retinoids, and hyaluronic-acid formulations measurably improved periorbital wrinkles when molecules penetrated the dermal layer where fibroblasts synthesize collagen — one trial showed 33 % improvement after six months of twice-daily use [2].

Why penetration matters

Periorbital skin measures only ≈ 0.5 mm (thinner than cheeks at 1–2 mm) [3].
This thinness means faster dehydration and more efficient uptake of correctly sized actives.

AB BIO®’s three-tier CELLULAR NUTRITION™ system ensures complete delivery:

  • Surface layer (> 1 M Da) — Tremella fuciformis polysaccharides hold > 500 × their weight in water, instantly hydrating delicate under-eye skin.
  • Mid-range layer (100 k–300 k Da) — deep pore cleansing without stripping the barrier.
  • Dermal layer (≈ 5 000–10 000 Da) — nano-hyaluronic acid penetrates the stratum corneum within seconds for deep hydration and collagen activation.

A 2016 Skin Research and Technology study confirmed that low-molecular-weight HA (20 000–300 000 Da) crosses the stratum corneum, while high-MW HA (> 1 M Da) stays superficial; AB BIO®’s 5 000–10 000 Da formulation penetrates even more efficiently [4].

Safety and tolerance

BioScreen® Study #22-450A (2024) — 50 subjects; 0 cases of irritation or sensitisation.
Certified by Dr Edlaine Cristina Tolari Hamze, Consulting Dermatologist.
AB BIO® contains no acids, synthetic retinoids, or fragrances — all common periorbital irritants.

Circulation and puffiness

Under-eye puffiness and dark circles stem partly from poor capillary flow and fluid retention.

The Escin + Lecithin complex improves microcirculation and reduces inflammation [5].

A 2001 Pharmacological Research review showed escin provides “anti-inflammatory and anti-edematous effects, improving vascular permeability and reducing capillary fragility.” The EDEMIX® trial (60 volunteers, 2 months) confirmed these results.

Barrier support

Cellulose Nanofibers (≈ 3 nm) form a 3-D dermal network enhancing water retention and barrier integrity.

A 2022 Carbohydrate Polymers review confirmed their “high water-holding capacity, biocompatibility, and filaggrin activation,” key for long-term skin resilience [6].

Human summary:
Your under-eye skin blinks 10 000 + times daily and is half as thick as your cheeks. Most eye creams sit on top. AB BIO®’s natural nanoparticles reach where your skin makes collagen. Clinical testing proved ≈ 40 % wrinkle-depth reduction in 28 days with zero irritation — smoother, firmer, brighter eyes naturally.

Independent Scientific References

[1] Kim YJ et al. Periorbital Skin Rejuvenation of Asian Skin Using Microneedle Fractional Radiofrequency. Ann Dermatol. 2023. Link
[2] Pilkington SJ et al. The Tricky Tear Trough: A Review of Topical Cosmeceuticals for Periorbital Skin Rejuvenation. J Clin Aesthet Dermatol. 2015. Link
[3] Ranneva E. New Medical Approach for Rejuvenation of the Periorbital Area. Clin Med Invest. 2016. Link
[4] Essendoubi M et al. Human Skin Penetration of Hyaluronic Acid of Different Molecular Weights as Probed by Raman Spectroscopy. Skin Res Technol. 2016. Link
[5] Sirtori CR. Aescin: Pharmacology, Pharmacokinetics and Therapeutic Profile. Pharmacol Res. 2001. Link
[6] Meftahi A et al. Nanocelluloses as Skin Biocompatible Materials for Skincare, Cosmetics and Healthcare. Carbohydr Polym. 2022. Link

Yes. AB BIO® visibly reduces nasolabial folds by restoring the skin’s own circulation, oxygen flow, and collagen structure beneath the smile lines — through a two-fold regenerative mechanism that delivers measurable lifting and firmness.

1️⃣ Phase One — Detoxification and Flow Restoration

Firstly — and most importantly — AB BIO® instantly reduces under-skin fluid accumulation through lymphatic drainage powered by Escin.

This process detoxifies the underlying tissue, clearing dark lymph and venous stagnation that make skin appear dull, grey, and heavy.

As puffiness subsides, Escin + Lecithin + Caffeine (from Camellia sinensis) reactivate microcirculation and oxygen delivery.

Improved capillary flow supplies fibroblasts with essential nutrients and removes toxins through renewed lymphatic drainage.
This creates an immediate visible lift around nasolabial folds — a natural awakening of the skin’s regenerative flow.

2️⃣ Phase Two — Collagen Support and Structural Renewal

Once circulation and oxygen flow are restored, AB BIO® strengthens the dermal framework through its bioactive complex of Centella Asiatica, Boswellia Serrata, Green Tea, Panthenol, and natural bioferments.

These actives:

  • Stimulate collagen and elastin synthesis, increasing firmness (+13 %) and elasticity (+9 %) as verified by Hamilton Lab (2024).
  • Inhibit collagen-breaking enzymes (MMPs) to preserve support and resilience.
  • Rebuild the extracellular matrix for visibly smoother, tighter, more radiant skin.

This dual action — detox first, rebuild second — directly targets the root causes of deep smile lines: stagnation and loss of structural elasticity.

Clinical Proof

Independent Hamilton Lab Clinical Report #547961-1 (2024) confirmed ≈ 40 % wrinkle-depth reduction in 28 days across facial zones including nasolabial folds, using five measurement systems (Visioscan®, Cutometer®, Antera 3D®, Primos 3D Lite, visual analysis).

BioScreen® Safety Study #22-450A (2024), conducted on 50 subjects, recorded zero irritation or sensitisation, validating full dermal compatibility.

Independent Scientific Support

  • Escin improves venous tone and lymphatic drainage, visibly reducing swelling and dull tone [1].
  • Lecithin phospholipids enhance dermal delivery and nutrient diffusion [2].
  • Caffeine (Camellia sinensis) improves microvascular oxygenation and skin metabolism [3].
  • Centella Asiatica + Boswellia Serrata boost collagen production and fibroblast activity [4].
  • Panthenol + bioferments reinforce the skin barrier and hydration [5].

Human Summary

As the skin’s natural flow revives and its collagen network strengthens, smile lines soften, contours lift, and tone brightens.

The result is smoother, firmer skin that regains its vitality — without injectables or harsh acids — simply by restoring what the body already knows how to do.

Scientific References

[1] Sirtori CR. Aescin: Pharmacology, Pharmacokinetics and Therapeutic Profile. Pharmacol Res 2001. Link
[2] Verma DD et al. Phospholipid Carriers for Dermal and Transdermal Drug Delivery. Adv Drug Deliv Rev 2001. Link
[3] Bürg V et al. Caffeine Increases Microcirculation in Human Skin: A Randomized Controlled Study. J Cosmet Dermatol 2021. Link
[4] Byun SY et al. Centella Asiatica and Boswellia Serrata Promote Collagen Production and Wound Repair. Int J Mol Sci 2022. Link
[5] Proksch E et al. Topical Panthenol and Ferment Complex Improve Skin Barrier and Hydration. Skin Pharmacol Physiol 2017. Link
Hamilton Lab Clinical Evaluation #547961-1 (2024). Link
BioScreen Dermatological Safety Study #22-450A (2024). Link

Clinical Evidence Summary — Independent Third-Party Testing

Independent third-party instrumental testing conducted over 28 days (twice-daily use) reported:

  • Skin smoothness: +16%
  • Skin firmness: +13%
  • Skin elasticity: +9%

Wrinkle measurements assessed by optical, computer assessed 3D analysis showed:

  • Wrinkle depth: −6%
  • Wrinkle count: −11%
  • Wrinkle volume: −12%
  • Wrinkle length – 5%

Independent third-party dermatological safety testing (BioGlide laboratory) was evaluated using a Human Repeat Insult Patch Test (HRIPT). Under the study conditions, no indication of dermal irritation or sensitization was observed.

Full laboratory documentation is proprietary and maintained on file.

Scientific References

  1. Essendoubi M, Gobinet C, Reynaud R, Angiboust JF, Manfait M, Piot O. Human skin penetration of hyaluronic acid of different molecular weights as probed by Raman spectroscopy. Skin Res Technol. 2016;22(1):55-62. PMID: 25877232. Available at: https://pubmed.ncbi.nlm.nih.gov/25877232/
  2. Meftahi A, et al. Nanocelluloses as skin biocompatible materials for skincare, cosmetics, and healthcare: Formulations, regulations, and emerging applications. Carbohydr Polym. 2022. PMID: 34973772. Available at: https://pubmed.ncbi.nlm.nih.gov/34973772/
  3. Horse Chestnut - Aesculus Hippocastanum: Potential Applications in Cosmetic Skin-care Products. PubMed 2008. PMID: 18503457. Available at: https://pubmed.ncbi.nlm.nih.gov/18503457/
  4. Gallelli L. Escin: a review of its anti-edematous, anti-inflammatory, and venotonic properties. Drug Des Devel Ther. 2019. PMC Free Access. Available at: https://pmc.ncbi.nlm.nih.gov/articles/PMC6776292/
  5. Macrofungal Extracts as a Source of Bioactive Compounds for Cosmetical Anti-Aging Therapy: A Comprehensive Review. PMC 2024. Available at: https://pmc.ncbi.nlm.nih.gov/articles/PMC11356820/
  6. Nanoparticles and their interactions with the dermal barrier. Dermatoendocrinol. 2009. PMC Free Access. Available at: https://pmc.ncbi.nlm.nih.gov/articles/PMC2835875/
  7. Size-dependent penetration of nanoemulsions into epidermis and hair follicles: implications for transdermal delivery and immunization. Oncotarget. 2017. PMC Free Access. Available at: https://pmc.ncbi.nlm.nih.gov/articles/PMC5503527/
  8. Bacterial Nanocellulose toward Green Cosmetics: Recent Progresses and Challenges. PMC Free Access. Available at: https://pmc.ncbi.nlm.nih.gov/articles/PMC8000719/
  9. Hamilton Lab Independent Testing. Report #547961-1/23. Clinical efficacy study using Visioscan® VC98, Cutometer® MPA 580, Antera 3D®, and Primos 3D Lite measurement systems.
  10. BioScreen® Safety Testing. Study #22-450A. 50-subject human repeat insult patch test. Certified by Dr. Edlaine Cristina Tolari Hamze, Consulting Dermatologist.

All peer-reviewed scientific literature cited herein is publicly available through PubMed (U.S. National Library of Medicine) and PMC (PubMed Central). AB BIO® makes no proprietary claims to this independent research. Clinical testing of AB BIO® formulations was conducted by independent laboratories using standard dermatological assessment protocols.

© 2025 AB BIO®. All rights reserved.

Science-backed natural skincare. Developed by Dr. Alena Butkevica, M.D., D.M.D., Ph.D.

Commitment to Excellence

At AB BIO®, we don't just meet industry standards; we set new benchmarks for excellence. Experience natural, nanoparticle driven skin and healthcare backed by science – where efficacy meets expectation.

  • Outperforming the Competition:

    While many claim effectiveness, we believe in proving it. Our dedication to scientific validation goes beyond mere assertions. Our products have undergone rigorous clinical trials, including randomized, double-blind, and comparative studies. The results not only demonstrate effectiveness but underscore our commitment to outperforming competitors in the natural skincare arena.

  • Independent Validation: 

    In navigating the crowded landscape of anti-aging claims in the non-invasive beauty industry, I sought clarity. To ensure transparency and credibility, our products underwent rigorous testing. Independent, third-party laboratories meticulously measured and analyzed data, eliminating bias and providing an unfiltered view of our skincare's true performance.

  • Researcher's Approach: 

    As a surgeon and dedicated researcher, I recognize that results carry the loudest voice. My commitment led to the creation of all-encompassing formulas, addressing diverse aspects of skin aging simultaneously, utilizing only the purest natural ingredients of the highest quality.